Carbon-Carbon Bond Formation Using Alkyl-Titanium-(IV) Compounds
- 1 January 1981
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 11 (3), 261-266
- https://doi.org/10.1080/00397918108061870
Abstract
Although alkyl-titanium-(IV) compounds have been used extensively as polymerization catalysts, practically nothing is known concerning their utility in synthetic organic chemistry1. As part of our systematic study directed toward exploring this unknown area, we have previously reported that 1) methyltitaniumtrichloride and dimethyltitaniumdichloride react smoothly with tertiary alkyl halides to form alkanes having quarternary carbon atoms2,3, 2) the above reagents as well as methyltitaniumtriisopropylate react with 2-phenylpropionaldehyde diastereoselectively to form the corresponding erythro and threo alcohols4 (up to 88:12 ratio), and 3) methyl-and phenyltitanium (IV) compounds add to aldehydes faster than to ketones.Keywords
This publication has 1 reference indexed in Scilit:
- Studies in Stereochemistry. X. The Rule of “Steric Control of Asymmetric Induction” in the Syntheses of Acyclic SystemsJournal of the American Chemical Society, 1952