THE RESPONSE OF HYPOPHYSECTOMIZED MICE TO INJECTIONS OF HUMAN SERUM CONTAINING LONG-ACTING THYROID STIMULATOR

Abstract

Human serum, obtained from a patient with Graves’s disease and containing a high level of long-acting thyroid stimulator, elicited highly significant responses when injected into hypophysectomized mice. The mean response did not differ significantly from that elicited in a control group of intact mice. This shows that the site of action of the abnormal thyroid stimulator is not the pituitary gland and makes it likely that the material acts directly on the thyroid.