Regional Cerebral Glucose Phosphorylation and Blood Flow After Insertion of a Microdialysis Fiber Through the Dorsal Hippocampus in the Rat
- 1 September 1987
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 49 (3), 729-734
- https://doi.org/10.1111/j.1471-4159.1987.tb00954.x
Abstract
Local cerebral glucose metabolism (LCMRglc) and local cerebral blood flow (LCBF) were studied following implantation of a microdialysis fiber in rat dorsal hippocampus. Recovery time after implantation varied from 0 to 24 h. All rats showed pronounced disturbances in LCMRglc and LCBF during the first 2 h of implantation. The changes consisted of (a) a general decrease in blood flow and glucose phosphorylation and (b) small areas (spots) around the fiber with increased glucose phosphorylation and decreased blood flow. Animals allowed to recover for 24 h demonstrated a near normalization of LCMRglu and LCBF, and the focal disturbances (spots) of glucose phosphorylation and blood flow disappeared. The slight reduction in blood flow and glucose metabolism at this time must be accepted, because extension of the recovery period beyond 24 h may give interpretation problems due to the developing gliosis.Keywords
This publication has 20 references indexed in Scilit:
- Ischemia-Induced Shift of Inhibitory and Excitatory Amino Acids from Intra- to Extracellular CompartmentsJournal of Cerebral Blood Flow & Metabolism, 1985
- Long-Lasting Reduction of Cortical Blood Flow of the Rat Brain after Spreading Depression with Preserved Autoregulation and Impaired CO2 ResponseJournal of Cerebral Blood Flow & Metabolism, 1984
- Regional brain glucose metabolism in chemically-induced seizures in the ratBrain Research, 1984
- Autoradiographic Determination of Regional Brain Glucose ContentJournal of Cerebral Blood Flow & Metabolism, 1983
- Effects of In Vivo Administration of Kainic Acid on the Extracellular Amino Acid Pool in the Rabbit HippocampusJournal of Neurochemistry, 1983
- Purine levels in the intact rat brain. Studies with an implanted perfused hollow fibreNeuroscience Letters, 1982
- Dopamine Synaptic Mechanisms Reflected in Studies Combining Behavioural Recordings and Brain DialysisPublished by Elsevier ,1982
- Simultaneous measurement of blood flow and glucose metabolism by autoradiographic techniques.Stroke, 1981
- Regional cerebral blood flow in the rat during prolonged seizure activityBrain Research, 1980
- Osmotic opening of the blood‐brain barrier and local cerebral glucose utilizationAnnals of Neurology, 1979