Characteristics of active Na transport in intact cardiac cells
- 1 February 1979
- journal article
- review article
- Published by American Physiological Society in American Journal of Physiology-Heart and Circulatory Physiology
- Vol. 236 (2), H189-H199
- https://doi.org/10.1152/ajpheart.1979.236.2.h189
Abstract
An active Na transport maintains the Na and K concentration gradients across the cell membrane of many cells and restores them following excitation. Heart muscle cells display frequent electrical discharges and thus the cardiac Na pump is of fundamental functional significance. Some methods for studying active Na transport are described. The active Na efflux from heart muscle cells is activated by an increase in the intracellular Na and the extracellular K concentration. The linkage between active Na efflux and active K influx varies widely according to the experimental conditions. The cardiac Na pump is electrogenic and can contribute directly to the membrane potential of the cells. The effects of active Na transport on contraction and intercellular coupling in myocardium are discussed.This publication has 4 references indexed in Scilit:
- Changes in the intracellular sodium activity of sheep heart Purkinje fibres produced by calcium and other divalent cations.The Journal of Physiology, 1978
- Effects of Na and K ions on the active Na transport in guinea-pig auriclesPflügers Archiv - European Journal of Physiology, 1976
- Intracellular sodium concentration and resting sodium fluxes of the frog heart ventricleThe Journal of Physiology, 1967
- Cat Heart Muscle In Vitro The Journal of general physiology, 1964