Spo11 and the Formation of DNA Double-Strand Breaks in Meiosis
- 19 May 2007
- book chapter
- Published by Springer Nature
- Vol. 2, 81-123
- https://doi.org/10.1007/7050_2007_026
Abstract
Meiotic recombination is carried out through a specialized pathway for the formation and repair of DNA double-strand breaks made by the Spo11 protein, a relative of archaeal topoisomerase VI. This review summarizes recent studies that provide insight to the mechanism of DNA cleavage by Spo11, functional interactions of Spo11 with other proteins required for break formation, mechanisms that control the timing of recombination initiation, and evolutionary conservation and divergence of these processes.Keywords
This publication has 258 references indexed in Scilit:
- Cyclin-Dependent Kinase Directly Regulates Initiation of Meiotic RecombinationCell, 2006
- The FK506 Binding Protein Fpr3 Counteracts Protein Phosphatase 1 to Maintain Meiotic Recombination Checkpoint ActivityCell, 2005
- A checkpoint control linking meiotic S phase and recombination initiation in fission yeastProceedings of the National Academy of Sciences, 2005
- Spatial organization and dynamics of the association of Rec102 and Rec104 with meiotic chromosomesThe EMBO Journal, 2004
- Direct Coupling Between Meiotic DNA Replication and Recombination InitiationScience, 2000
- The 3' to 5' degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3' to 5' exonucleases of the exosome complexThe EMBO Journal, 1998
- Meiosis-Specific DNA Double-Strand Breaks Are Catalyzed by Spo11, a Member of a Widely Conserved Protein FamilyCell, 1997
- Meiotic cells monitor the status of the interhomolog recombination complex.Genes & Development, 1997
- Temporal comparison of recombination and synaptonemal complex formation during meiosis in S. cerevisiaeCell, 1991
- Meiotic effects of DNA-defective cell division cycle mutations of Saccharomyces cerevisiaeChromosoma, 1978