Contact inhibition and malignancy
- 27 September 1979
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 281 (5729), 259-262
- https://doi.org/10.1038/281259a0
Abstract
The role of contact inhibition in influencing the behaviour of malignant cells is discussed in a review. Although tissue culture cannot simulate the immense complexity of the conditions in vivo, some of the distinctive features of malignant invasion can be conveniently observed with this technique. The evidence derived from this technique indicates that defective contact inhibition of movement of malignant cells does contribute to their invasiveness.Keywords
This publication has 16 references indexed in Scilit:
- Invasive Behavior Between Sarcoma and Fibroblast Populations in Cell Culture 2JNCI Journal of the National Cancer Institute, 1976
- Adhesions of fibroblasts to substratum during contact inhibition observed by interference reflection microscopyExperimental Cell Research, 1975
- Overlapping of normal and malignant mouse cells in pure and mixed culturesExperimental Cell Research, 1974
- Some findings on movement and contact of human normal and tumour cells in vitroEuropean Journal of Cancer (1965), 1973
- Cell locomotion and contact inhibition of normal and neoplastic rat cellsInternational Journal of Cancer, 1973
- Scanning electron microscopic observations of chick embryo fibroblasts in vitro, with particular reference to the movement of cells under othersCell and tissue research, 1969
- The monolayering in tissue culture of fibroblasts from different sourcesProceedings of the Royal Society of London. B. Biological Sciences, 1968
- Interference microscope studies of cell contacts in tissue cultureExperimental Cell Research, 1958
- Social behaviour of cells in tissue cultureExperimental Cell Research, 1957
- Observations on the social behaviour of cells in tissue cultureExperimental Cell Research, 1954