Cystic fibrosis: typing 89 German families with linked DNA probes
- 1 December 1988
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 81 (1), 54-56
- https://doi.org/10.1007/bf00283729
Abstract
Three hundred and ninety-two subjects from 89 German families were typed for restriction fragment length polymorphisms (RFLPs) detected by the probes pmetH, pmetD, pJ3.11, KM19, and XV2c known to be tightly linked to the cystic fibrosis (CF) gene. The analysis of the predictive value of this typing in individual CF families indicates that the combined use of these probes provides a powerful diagnostic system for both carrier detection and prenatal diagnosis. In 45 families the complete haplotype including all RFLPs was available. Of them 41 (91.1%) were fully informative and 4 were partly informative.Keywords
This publication has 9 references indexed in Scilit:
- GENETIC DIFFERENCES BETWEEN CYSTIC FIBROSIS WITH AND WITHOUT MECONIUM ILEUSThe Lancet, 1988
- Patterns of polymorphism and linkage disequilibrium for cystic fibrosisGenomics, 1987
- A candidate for the cystic fibrosis locus isolated by selection for methylation-free islandsNature, 1987
- Cystic fibrosis: typing 48 German families with linked DNA probesHuman Genetics, 1987
- LINKAGE OF CYSTIC-FIBROSIS TO 2 TIGHTLY LINKED DNA MARKERS - JOINT REPORT FROM A COLLABORATIVE STUDY1986
- FIRST-TRIMESTER PRENATAL DIAGNOSIS OF CYSTIC FIBROSIS WITH LINKED DNA PROBESThe Lancet, 1986
- Localization of cystic fibrosis locus to human chromosome 7cen–q22Nature, 1985
- A closely linked genetic marker for cystic fibrosisNature, 1985
- Analysis of Multilocus Pedigree Data by ComputerPublished by Springer Nature ,1984