Peptides from regenerating central nervous system promote specific populations of macroglia.
- 1 June 1985
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 82 (12), 4287-4290
- https://doi.org/10.1073/pnas.82.12.4287
Abstract
The regenerating CNS of goldfish contains peptides referred to as glia-promoting factors (GPF) that stimulate the proliferation of mammalian macroglia. In vitro, GPF1 and GPF3 promote the appearance of oligodendroglia and GPF2 and GPF4 stimulate proliferation of astroglia. The activities of GPF1, GPF3 and GPF4 increase during regeneration of the goldfish visual system. Brain peptides may play a role in the recovery of the injured CNS by regulating the growth and development of specific macroglial populations.This publication has 19 references indexed in Scilit:
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