Daily amylin replacement reverses hepatic glycogen depletion in insulin‐treated streptozotocin diabetic rats
- 5 August 1991
- journal article
- Published by Wiley in FEBS Letters
- Vol. 287 (1-2), 203-205
- https://doi.org/10.1016/0014-5793(91)80051-4
Abstract
In streptozotocin-diabetic rats treated with insulin replacement, liver glycogen is some 35% depleted. Five consecutive daily subcutaneous injections with amylin dose-dependently restored liver glycogen to normal levels. Significant increases over insulin-only therapy occurred with amylin doses of 10, 30 and 100 micrograms/day, representing amylin: insulin ratios of 0.22, 0.75 and 2.79.Keywords
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