Development of a High-Throughput Screening Assay for Inhibitors of Aggrecan Cleavage Using Luminescent Oxygen Channeling (AlphaScreen™)
Open Access
- 1 April 2003
- journal article
- research article
- Published by Elsevier in SLAS Discovery
- Vol. 8 (2), 149-156
- https://doi.org/10.1177/1087057103252308
Abstract
No abstract availableKeywords
This publication has 19 references indexed in Scilit:
- Articular cartilage and changes in arthritis: Matrix degradationArthritis Research & Therapy, 2001
- Mechanisms involved in cartilage proteoglycan catabolismMatrix Biology, 2000
- Purification and Cloning of Aggrecanase-1: A Member of the ADAMTS Family of ProteinsScience, 1999
- Aggrecanase: A Target for the Design of Inhibitors of Cartilage DegradationAnnals of the New York Academy of Sciences, 1999
- Inhibition of bovine nasal cartilage degradation by selective matrix metalloproteinase inhibitorsBiochemical Journal, 1997
- Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent.Journal of Clinical Investigation, 1996
- Interleukin-1 and Oncostatin M in Combination Promote the Release of Collagen Fragments from Bovine Nasal Cartilage in CultureBiochemical and Biophysical Research Communications, 1995
- Development of a cleavage-site-specific monoclonal antibody for detecting metalloproteinase-derived aggrecan fragments: detection of fragments in human synovial fluidsBiochemical Journal, 1995
- Monoclonal antibodies that specifically recognize neoepitope sequences generated by ‘aggrecanase’ and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitroBiochemical Journal, 1995
- Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin b and an inhibitor of matrix metalloproteinases. evidence for two converging pathways of chondrocyte‐mediated proteoglycan degradationArthritis & Rheumatism, 1993