Effects of Intravenous Injection in Dogs of Staphylokinase and Dog Serum Fibrinolysin.

Abstract

Fibrinolysin, prepared from dog serum, and staphylokinase, a known activator of dog profibrinolysin, were intraven. injd., in separate expts., into anesthetized dogs. After the injn. of fibrinolysin early samples showed accelerated clotting (possibly due to some thrombin contaminant in the enzyme prepn.), followed by lysis of the clot, while later samples were incoagulable and contained no demonstrable fibrinogen. Serum studies showed the appearance of active lysin, a marked fall in antilysin and no apparent change in prolysin. Following the injn. of staphylokinase clot lysis succeeded by incoagulable blood was again observed. The kinase produced in vivo activation of the natural serum prolysin, the latter disappearing as active fibrinolysin formed, while the antilysin fell to extremely low values. Both prepns. caused fall in blood pressure more marked with staphylokinase.