The use of an immobilized aldolase in the first synthesis of a natural deaminated neuraminic acid

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Abstract
The first synthesis of 3-deoxy-D-glycero-D-galacto-nonulosonic acid (KDN)(1) was achieved by condensation of the non-nitrogeneous substrate D-mannose (2) with pyruvate, catalysed by immobilized acylneuraminate pyruvate lyase.