Effect of an oestrogen synthesis inhibitor, 1,4,6-androstatriene-3,17-dione, on mouse embryo development in vitro
- 1 September 1982
- journal article
- research article
- Published by Bioscientifica in Reproduction
- Vol. 66 (1), 63-66
- https://doi.org/10.1530/jrf.0.0660063
Abstract
Mouse embryos (4-8 cells) were cultured for 48 h in vitro in medium containing 1,4,6-androstatriene-3,17-dione (ATD). Inhibition of embryo development by ATD was overcome by estradiol-17.beta. but not by estradiol-17.alpha.. Culture with ATD for the first and second 24 h led to normal numbers of blastocysts. Preimplantation mouse embryos contain the enzymic machinery for synthesis of estrogen.This publication has 3 references indexed in Scilit:
- Oestrogen production by blastocyst and early embryonic tissue of various speciesReproduction, 1980
- Blockade of Testosterone-Induced Mounting Behavior in the Male Rat with Intracranial Application of the Aromatization Inhibitor, Androst-l,4,6-triene-3,17-dioneEndocrinology, 1975
- Nutrient Requirements for the Culture of Preimplantation Embryos in VitroPublished by Elsevier ,1971