Reactions of the Trichloromethylperoxy Free Radical (Cl3COO.) with Tryptophan, Tryptophanyl-tyrosine and Lysozyme

Abstract

The trichloromethyl peroxy radical Cl₃COO. reacts with tryptophan, tryptophanyl-tyrosine and with lysozyme to form products whose overall absorption spectrum is different from those observed following the reaction of hydroxyl, bromide, thiocyanate or azide radicals. Two spectral components have been identified: a minor component attributed to the neutral tryptophanyl radical which can react with ascorbate and intramolecularly with tyrosine residues and a major component which does not undergo either of these reactions and is probably a radical adduct.