Mode of hemolytic action of the antifungal polyene antibiotic filipin
Open Access
- 1 January 1966
- journal article
- research article
- Published by Walter de Gruyter GmbH in Zeitschrift für Naturforschung B
- Vol. 21 (1), 74-77
- https://doi.org/10.1515/znb-1966-0120
Abstract
Filipin at low concentrations rapidly hemolyzes bovine erythrocytes. Of the known constituents of cell membranes tested, only cholesterol and phosphatidyl-choline prevented hemolysis. A specific complex was formed only with cholesterol. Filipin treatment caused a release of cholesterol from erythrocytes. Since all sterol is located in the cell membrane, the hemolytic action of filipin may be due to a displacement of cholesterol from the cell membrane thus weakening its stability. The internal pressure of the cell then could force the hemoglobin through the defective membrane.This publication has 9 references indexed in Scilit:
- The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytesArchives of Biochemistry and Biophysics, 1963
- The lytic effect of polyene antifungal antibiotics on mammalian erythrocytesBiochemical and Biophysical Research Communications, 1962
- LOCATION AND ROLE OF STEROL AT NYSTATIN-BINDING SITESJournal of Bacteriology, 1962
- NYSTATIN BINDING BY PROTOPLASTS AND A PARTICULATE FRACTION OF NEUROSPORA CRASSA, AND A BASIS FOR THE SELECTIVE TOXICITY OF POLYENE ANTIFUNGAL ANTIBIOTICSProceedings of the National Academy of Sciences, 1962
- ALTERATIONS IN THE PERMEABILITY OF NEUROSPORA CRASSA DUE TO POLYENE ANTIBIOTICSJournal of Bacteriology, 1961
- Effect of High Concentrations of Nystatin upon Glycolysis and Cellular Permeability in Yeast.Experimental Biology and Medicine, 1961
- INHIBITION OF ALGAE BY NYSTATINJournal of Bacteriology, 1961
- ACTION OF AN ANTIFUNGAL ANTIBIOTIC NYSTATIN, ON PROTOZOA LEISHMANIA DONOVANI .2. STUDIES ON RELEASE OF INTRACELLULAR CONSTITUENTS1961
- MECHANISM OF PROTECTION BY STEROLS AGAINST POLYENE ANTIBIOTICSJournal of Bacteriology, 1960