Extracellular phospholipase A2 activity in cell free peritoneal lavage fluid from mice with zymosan peritonitis
- 1 June 1989
- journal article
- Published by Springer Nature in Inflammation Research
- Vol. 27 (3-4), 341-343
- https://doi.org/10.1007/bf01972817
Abstract
The kinetics and appearance of extracellular phospholipase A2 (PLA2) activity and its relationship to the appearance of arachidonic acid (AA) metabolites in the peritoneal cavity of mice injected with zymosan is described. AA metabolites levels including leukotriene C4 (LTC4) were maximum 15–30 min after zymosan. Peak PLA2 activity was also found 15–30 min after zymosan and was significantly increased above levels found in saline control exudates (3.83±0.89 and 0.35±0.11, respectively,p≤0.05). Results show that an extracellular PLA2 is present in zymosan peritonitis.This publication has 7 references indexed in Scilit:
- Inhibition of phospholipase A2 by "lipocortins" and calpactins. An effect of binding to substrate phospholipids.Journal of Biological Chemistry, 1987
- Extracellular Phospholipase A2 Activity in Peritoneal Cavity of Casein-Treated Rats1The Journal of Biochemistry, 1986
- Intraperitoneal injection of zymosan in mice induces pain, inflammation and the synthesis of peptidoleukotrienes and prostaglandin E2Prostaglandins, 1985
- Phospholipase A2 activity in carrageenin-induced inflammatory tissue of ratsBiochemical Pharmacology, 1982
- Purification and characterization of a potent bactericidal and membrane active protein from the granules of human polymorphonuclear leukocytes.Journal of Biological Chemistry, 1978
- Phospholipases and phospholipid turnover in Escherichia coli spheroplastsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1972