Pharmacokinetics of Sulfadoxine‐Pyrimethamine in HIV‐Infected and Uninfected Pregnant Women in Western Kenya

Abstract

Background. Sulfadoxine-pyrimethamine (SP) is among the most commonly used antimalarial drugs during pregnancy, yet the pharmacokinetics of SP are unknown in pregnant women. HIV-infected (HIV+) women require more frequent doses of intermittent preventive therapy with SP than do HIV-uninfected (HIV^-) women. We investigated whether this reflects their impaired immunity or an HIV-associated alteration in the disposition of SP.