Temporolimbic Volume Reductions in Schizophrenia

Abstract

TEMPORAL LOBE structures and circuitry modulate cognition and emotion, prompting their neuroanatomic examination in schizophrenia. Investigations with magnetic resonance imaging (MRI) have evaluated lobar volumes^1-5 and specific subregions^6-15 implicated in neurobehavioral domains aberrant in schizophrenia, such as memory. Regional volumes have also been linked to clinical features, including thought disorder and auditory hallucinations.^7,8 This research complements neuropathological findings documenting abnormal morphometry, cytoarchitecture, and neuroreceptors in temporolimbic structures.^16-18