DISTRIBUTION PATTERN OF A NON-STEROID COMPOUND WITH ENDOCRINE ACTIONS, 14C-BIS(P-HYDROXYPHENYL)CYCLOHEXYLIDENEMETHANE (COMPOUND F6060) AND ITS DIACETATE (COMPOUND F6066)
- 1 September 1965
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 50 (1), 35-43
- https://doi.org/10.1530/acta.0.0500035
Abstract
While testing a series of unsymmetrical diphenylalkenes, it was observed that bis(p-hydroxyphenyl)cyclohexylidenemethane (compound F6060) and its diacetate (compound F6066) had an estrogenic activity of about 1/1000 that of oestradiol benzoate. Further pharmacological investigations showed antiestrogenic (chicken oviduct test) and anti-gestagenic (Clauberg test) properties. The compounds had a low toxicity both in acute and chronic tests. In order to further elucidate the physiology of the compounds they were labelled with C14 and their distribution in the body was investigated by whole body autoradiography in male and female (pregnant) mice. A rapid and selective accumulation of both compounds was observed in the corpora lutea. A selective and progressively increasing accumulation was also seen in the visceral yolk sac epithelium. A slight accumulation was also found in the hypophysis, the adrenal cortex, the endometrium, the interstitial tissue of the testis and ovary, the epididymis and the mucosa of the seminal vesicles. No accumulation was found in the prostate. There was a very low concentration in the fetus during the whole course of observation. In addition to the radioactivity in the liver, bile and intestinal lumen, the only organs showing any retention 24 hours after administration were the corpora lutea and yolk sac epithelium.This publication has 4 references indexed in Scilit:
- EFFECT OF BIS(P-ACETOXYPHENYL)CYCLOHEXYLIDENE-METHANE (COMPOUND F 6066) ON HORMONE EXCRETION IN POSTMENOPAUSAL WOMEN1965
- Synthesis of Unsymmetrical Diphenylalkenes1Journal of Medicinal Chemistry, 1963
- DISTRIBUTION OF INJECTED 14C-OESTRONE AND 14C-DIETHYLSTILBOESTROLActa Endocrinologica, 1963
- AUTORADIOGRAPHIC DISTRIBUTION STUDIES WITH NATURAL OESTROGENSActa Endocrinologica, 1963