Abstract
Changes in the nucleic acid apparatus of the rat liver cell during the appearance of basophilic rods were studied by determination of total N and ribose nucleic acid/unit desoxyribose nucleic acid and nucleolar volume during the administration of organic I, epinephrine and increased muscular work. The transformation of the normal coarse, basophilic inclusion into basophilic rods was in all instances accompanied by a decrease in the amount of total N and ribose nucleic acid/cell. Nucleolar volume increased during administration of organic I but remained unchanged under the other conditions.