Abstract
In 1912, Bowen1reported a study of two cases of chronic atypical epithelial proliferation to which he gave the designation of precancerous dermatosis. Since then, this condition has been the subject of investigation by many workers, including Darier,2Highman,3Fraser,4Wise5and others. A great deal has been written regarding its exact status in the field of neoplastic growths, but most dermatopathologists are in accord with Fraser, who believes that "the cellular changes constituting this lesion are, from the beginning, those generally considered as characteristic of malignancy." He pointed out that pathologically "the cells in the Bowen lesion have already undergone the changes of malignant neoplasia, and for this reason the lesion should be classified as an intraepidermal carcinoma." As Wise5has pointed out, a definite diagnosis of Bowen's disease cannot be made on clinical evidence, but only on characteristic microscopic