Helix-coil transformation and titration curve of poly-L-glutamic acid
- 1 September 1960
- journal article
- research article
- Published by Taylor & Francis in Molecular Physics
- Vol. 3 (5), 409-416
- https://doi.org/10.1080/00268976000100441
Abstract
The titration curve of poly-L-glutamic acid was studied in connection with the helix-coil transformation. In aqueous solution the transformation has its origin in the ionization of the polar group COOH in the side chain. Conversely the ionization and the titration curve of this molecule are affected by the change of the electrostatic interaction produced by its transformation. It is shown in this report that the experimental result, the titration curve and its modified plot, can be divided into three sections, that is, the ionization of the perfect helix, the region of the helix-coil transformation, and the ionization of the perfect coil.Keywords
This publication has 9 references indexed in Scilit:
- Proteins and Synthetic PolypeptidesAnnual Review of Physical Chemistry, 1959
- High Molecular Weight Poly-α,L-glutamic Acid: Preparation and Optical Rotation Changes1Journal of the American Chemical Society, 1958
- Polypeptides. VIII. Molecular configurations of poly‐L‐glutamic acid in water‐dioxane solutionJournal of Polymer Science, 1957
- Polypeptides. III. The Synthesis of High Molecular Weight Poly-γ-benzyl-L-glutamates1Journal of the American Chemical Society, 1956
- POLYPEPTIDES. VII. POLY-γ-BENZYL-L-GLUTAMATE: THE HELIX-COIL TRANSITION IN SOLUTION1Journal of the American Chemical Society, 1956
- Approximate calculation of the electrostatic free energy of nucleic acids and other cylindrical macromoleculesArchives of Biochemistry and Biophysics, 1955
- Thermodynamic Considerations of Protein Reactions.1,2 I. Modified Reactivity of Polar GroupsJournal of the American Chemical Society, 1954
- POLYPEPTIDES. II. THE CONFIGURATION OF POLYMERS OF γ-BENZYL-L-GLUTAMATE IN SOLUTION1Journal of the American Chemical Society, 1954
- The electrostatic free energy of polyelectrolyte solutions. I. Randomly kinked macromoleculesJournal of Polymer Science, 1953