TESTOSTERONE TREATMENT AND 17-KETOSTEROID EXCRETION

Abstract
In normal healthy male subjects the daily urinary 17-ketosteroid (17-KS) excretion was measured before and after single intramuscular injections of testosterone [beta]-cyclopentylpropionate (I) (1000 mg in oily solution), testosterone furanate (II) (1000 mg microcrystals in aqueous suspension), and testosterone oenanthate (III) (390 mg in oily solution). The period of increased 17-KS excretion and the percentage recovery were determined for each of these compounds and compared with those of other testosterone esters. III and I were intermediate between testosterone propionate in oil and testosterone iso-butyrate microcrystals, HI having a shorter duration of action (6-8 days) than I (10-13 days). II was not recovered as 17-ketosteroid.