Immunofluorescent Studies in Renal Biopsies in Pre-eclampsia
- 16 March 1974
- Vol. 1 (5906), 473-476
- https://doi.org/10.1136/bmj.1.5906.473
Abstract
Renal biopsies were performed on 11 patients considered clinically and histologically to have pre-eclampsia. Immunofluorescent studies with fluorescein-labelled anti-IgG, IgA, IgM, and IgE complement, albumin, fibrin, and fibrinogen were carried out on the tissue obtained. Significant correlation was obtained between the clinical severity of the disease and the density and pattern of IgM and IgG deposition. Complement was found in glomeruli in severe cases, while complement deposition in the walls of afferent and efferent arterioles was a constant finding. These findings support the concept that an immunological mechanism may be responsible for the renal lesions in pre-eclampsia. If immunity does play a part in the pathogenesis of pre-eclampsia, possible mechanisms include the involvement of histocompatibility antigens and cross-reactivity of fetal and maternal tissues. Renal fibrin deposition in pre-eclampsia may be secondary to an immune process, an occurrence well-described in other forms of glomerulonephritis in man and other species.Keywords
This publication has 24 references indexed in Scilit:
- THE RENAL LESIONS OF TOXAEMIA AND ABRUPTIO PLACENTAE STUDIED BY LIGHT AND ELECTRON MICROSCOPYBJOG: An International Journal of Obstetrics and Gynaecology, 1972
- COAGULATION, FIBRINOLYSIS AND PLATELET FUNCTION IN PRE‐ECLAMPSIA, ESSENTIAL HYPERTENSION AND PLACENTAL INSUFFICIENCYBJOG: An International Journal of Obstetrics and Gynaecology, 1971
- Coagulation and Fibrinolytic Systems in Pre-eclampsia and EclampsiaBMJ, 1971
- Experimental defibrination III: The maternal and foetal microcirculation following placental separation or traumaMicrovascular Research, 1969
- HEPARIN TREATMENT OF HAEMOLYSIS AND THROMBOCYTOPENIA IN PRE‐ECLAMPSIABJOG: An International Journal of Obstetrics and Gynaecology, 1967
- The pathological response of the vessels of the placental bed to hypertensive pregnancyThe Journal of Pathology and Bacteriology, 1967
- PLASMA RENIN CONCENTRATION IN THE HYPERTENSIVE DISEASES OF PREGNANCYBJOG: An International Journal of Obstetrics and Gynaecology, 1966
- Vascular Changes in the Placental BedPathobiology, 1961
- The Kidney in Toxemia of PregnancyMedicine, 1960
- REVERSIBLE GLOMERULAR LESIONS IN TOXEMIA OF PREGNANCYThe Lancet, 1956