Relationship between Fluoride in the Drinking Water and the Plasma Fluoride Concentration in Man

Abstract

The plasma fluoride concentration in 15 subjects living in three different districts with 9.6, 1.2 and 0.25 ppm fluoride in the drinking water, was followed over 36 h. In the 9.6-ppm-fluoride area there was a wide fluctuation in the plasma fluoride concentration during the day compared to the 1.2- and 0.25-ppm-fluoride areas. A correlation coefficient of 0.71 was found between renal clearance of F and urinary flow. The results of this study illustrate the necessity for frequent or standardized blood sampling in studies on plasma fluoride concentrations in man.