Serum Protein Binding of the Aminoglycoside Antibiotics

Abstract

The binding of four aminoglycoside antibiotics by human serum was investigated under controlled conditions of physiological p H and temperature, by means of an ultrafiltration technique. No serum binding was demonstrable for gentamicin, tobramycin, or kanamycin, whereas streptomycin was 35% bound. Previous conflicting studies are discussed, and some of the pharmacological implications are considered.