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Comparative Goitrogenic Activity of Tapazole and Carbimazole in Cattle
Home
Publications
Comparative Goitrogenic Activity of Tapazole and Carbimazole in Cattle
Comparative Goitrogenic Activity of Tapazole and Carbimazole in Cattle
BP
B. N. Premachandra
B. N. Premachandra
GP
G. W. Pipes
G. W. Pipes
CT
C. W. Turner
C. W. Turner
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1 May 1960
journal article
Published by
Oxford University Press (OUP)
in
Journal of Animal Science
Vol. 19
(2)
,
553-559
https://doi.org/10.2527/jas1960.192553x
Abstract
The comparative goitrogenicity of two compounds, tapazole (1-methyl, 2-mercaptoimidazole) and carbimazole (1-methyl, 2-thio, 3-carbethoxyi-midazole) was determined in cattle by I
131
uptake suppression and by I
131
release measurements. By the former measurement carbimazole and tapazole were found equipotent and 3 gm./1000 lb. body weight completely blocked thyroxine secretion. By I
131
release rate measurements, however, carbimazole was about twice as potent as tapazole in blocking thyroxine synthesis. The implications of the differences in the potency of the goitrogens by different techniques are discussed. Copyright © . .
Keywords
CATTLE
CARBIMAZOLE
SECRETION
COPYRIGHT
METHYL
MERCAPTOIMIDAZOLE
FORMER
GOITROGENIC
TAPAZOLE
EQUIPOTENT
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Cited by 4 articles