Interferon production by human and murine lymphocytes in response to alloantigens.
- 1 October 1980
- journal article
- research article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 125 (4), 1589-1595
- https://doi.org/10.4049/jimmunol.125.4.1589
Abstract
The production of interferon (IF) by human and mouse lymphocytes sensitized to alloantigens in mixed lymphocyte cultures (MLC) was analyzed. During primary MLC, IF appeared in the culture fluid on day 2 and was maximal on day 5. Based on several biologic criteria, the IF produced is of the "immune" type. When lymphocytes sensitized to alloantigens were reestimulated in vitro, IF was produced within a few hours of culture. In all stimulated cultures, cell proliferation was observed in spite of the high concentrations of IF. The IF-producing cells in human MLC were identified as T lymphocytes lacking the receptor for the Fc fragment of IgG molecules (Fc gamma R(-)). Human MLC supernatants containing immune type IF mediate the enhancement of natural killer (NK) cell activity and protect NK target cells from lysis.This publication has 12 references indexed in Scilit:
- Human Leucocyte Interferon: Analysis of Effect on MLC and Effector Cell GenerationScandinavian Journal of Immunology, 1979
- Interferon production in the murine mixed lymphocyte culture. I. Interferon production caused by differences in the H‐2 K and H‐2 D region but not by differences in the I region or the M locusEuropean Journal of Immunology, 1979
- Cultivation with K562 cells leads to blastogenesis and increased cytotoxicity with changed properties of the active cells when compared to fresh lymphocytesCellular Immunology, 1978
- Time and dosoge dependence of immunoenhancement by murine type II interferon preparationsCellular Immunology, 1978
- Spontaneous Cell-Mediated Cytotoxicity in Humans: Role of Interferon and ImmunoglobulinsThe Journal of Immunology, 1978
- Anti-viral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. Enhancement of human natural killer cell activity by interferon and antagonistic inhibition of susceptibility of target cells to lysis.The Journal of Experimental Medicine, 1978
- Anti-viral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. Identification of the anti-viral activity as interferon and characterization of the human effector lymphocyte subpopulation.The Journal of Experimental Medicine, 1978
- Regulatory Effect of Interferon on T Cells in VitroThe Journal of Immunology, 1976
- Interferon-Like Virus-Inhibitor Induced in Human Leukocytes by PhytohemagglutininScience, 1965
- The Development of Large Immature Mononuclear Cells in Mixed Leukocyte CulturesBlood, 1964