Overtone mobility spectrometry: Part 2. Theoretical considerations of resolving power
- 1 May 2009
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Society for Mass Spectrometry
- Vol. 20 (5), 738-750
- https://doi.org/10.1016/j.jasms.2009.01.001
Abstract
The transport of ions through multiple drift regions is modeled to develop an equation that is useful for an understanding of the resolving power of an overtone mobility spectrometry (OMS) technique. It is found that resolving power is influenced by a number of experimental variables, including those that define ion mobility spectrometry (IMS) resolving power: drift field (E), drift region length (L), and buffer gas temperature (T). However, unlike IMS, the resolving power of OMS is also influenced by the number of drift regions (n), harmonic frequency value (m), and the phase number (Φ) of the applied drift field. The OMS resolving power dependence upon the new OMS variables (n, m, and Φ) scales differently than the square root dependence of the E, L, and T variables in IMS. The results provide insight about optimal instrumental design and operation.Keywords
This publication has 51 references indexed in Scilit:
- Two-Dimensional Gas-Phase Separations Coupled to Mass Spectrometry for Analysis of Complex MixturesAnalytical Chemistry, 2005
- Anhydrous Protein IonsChemical Reviews, 1999
- Gas-Phase Separations of Electrosprayed Peptide LibrariesAnalytical Chemistry, 1999
- Electrospray Ionization High-Resolution Ion Mobility Spectrometry−Mass SpectrometryAnalytical Chemistry, 1998
- Ion Mobility Measurements and their Applications to Clusters and BiomoleculesJournal of Mass Spectrometry, 1997
- Measuring the Resolving Power of Ion Mobility SpectrometersAnalytical Chemistry, 1994
- Electronic-state chromatography: application to first-row transition-metal ionsThe Journal of Physical Chemistry, 1991
- Ion Mobility Spectrometry in Analytical ChemistryCritical Reviews in Analytical Chemistry, 1990
- Transport Properties of Ions in GasesPublished by Wiley ,1988
- Theory of plasma chromatography/gaseous electrophoresis. ReviewAnalytical Chemistry, 1975