EFFECTS OF CRYSTALLINE ESTRIN IMPLANTS ON THE TIBIA OF YOUNG HYPOPHYSECTOMIZED FEMALE RATS

Abstract
A parallel study of previously reported crystalline estrin implants on the bone histology of normal young [female] rats (1) was repeated in hypophysectomized rats of the same sex and age. The typical picture of hyper-ossification of the proximal sub-epiphyseal zone of the tibia was not produced in the absence of the hypophysis.