A model for cytochrome oxidase.
- 1 July 1976
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 73 (7), 2206-2210
- https://doi.org/10.1073/pnas.73.7.2206
Abstract
A model is proposed for the active center of cytochrome c oxidase (ferrocytochrome c:oxygen oxidoreductase, EC 1.9.3.1) in which cytochrome a is a low-spin ferrihemoprotein and cytochrome a3 is a high-spin ferrihemoprotein antiferromagnetically coupled to 1 of the 2 Cu2+ ions present in the enzyme. Reduction may then be accompanied by a conformational change in the enzyme thus exposing the 6th coordination site of cytochrome a3 to ligands. This model accounts for a variety of observations including the results of magnetic circular dichroism, Mossbauer and EPR spectroscopies, as well as magnetic susceptibility measurements.This publication has 25 references indexed in Scilit:
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