MIGRATION OF LYMPHOBLASTS TO THE SMALL-INTESTINE .3. STRAIN DIFFERENCES AND RELATIONSHIP TO DISTRIBUTION AND DURATION OF TRICHINELLA-SPIRALIS INFECTION

Abstract

In NIH strain mice, in which the majority of T. spiralis are located in the anterior half of the small intestine early in the enteral phase of infection, enhanced localization of mesenteric lymphoblasts, nylon wool separated mesenteric T [thymus-derived] lymphoblasts and even oxazolone sensitized peripheral lymphoblasts is most prominent in the anterior region of the small intestine. As the worms move to the posterior half of the small intestine, enhanced localization of lymphoblasts is observed in that region only. In BALB/c mice, in which most of the worms are located in the posterior half of the small intestine, enhanced localization of lymphoblasts is primarily in that region. Expulsion of the worms commences within 2-3 days of a large increase in the number of lymphoblasts localizing in the anterior region of the small intestine in NIH strain mice and likewise follows a 2nd and larger increase in the number of lymphoblasts localizing in the posterior region of the small intestine of BALB/c mice.