TIME-DEPENDENT, IRREVERSIBLE INHIBITION OF "3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE BY ANTIBIOTIC CITRININ
- 1 January 1977
- journal article
- research article
- Vol. 488 (1), 97-101
Abstract
The inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase by citrinin, an antibiotic, was studied. The inhibition was the mixed type with respect to 3-hydroxy-3-methylglutaryl-CoA and non-competitive with respect to NADPH. When the enzyme was preincubated with citrinin prior to enzyme assay, it caused a time-dependent, irreversible inhibition, possibly by binding to a site distinct from the active center on the enzyme protein.This publication has 3 references indexed in Scilit:
- INHIBITION OF STEROL SYNTHESIS BY CITRININ IN A CELL-FREE SYSTEM FROM RAT-LIVER AND YEAST1977
- Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in hepatoma tissue culture cells by pure cholesterol and several cholesterol derivatives. Evidence supporting two distinct mechanisms.20l.Journal of Biological Chemistry, 1976
- Citrinin, an inhibitor of cholesterol synthesis.The Journal of Antibiotics, 1976