The Influence of Sex on the Catabolism of Griseofulvin

Abstract

Blood griseofulvin levels have been determined on rats given a single oral, subcutaneous, intraperitoneal or intravenous dose and on guinea pigs and human volunteers after oral administration. In rats the blood levels of females were higher than those of males: this applied to all four routes of administration. No differences in blood levels between males and females were observed in guinea pigs or human volunteers. In vitro studies have shown that liver slices obtained from male rats destroy griseofulvin more rapidly than those from females; the sex difference did not apply to rabbits or guinea pigs.