Affinity labelling of estradiol receptor by ferrocenyl tagging of estradiol 17α-position
- 1 January 1990
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 11,p. 837-839
- https://doi.org/10.1039/c39900000837
Abstract
The introduction of a ferrocenyl moiety at the 17α-position of estradiol brings about a dramatic change in the behaviour of the hormone at the receptor binding site since an irreversible binding takes place; this unusual reactivity may help to elucidate the steroid's mode of action.Keywords
This publication has 13 references indexed in Scilit:
- Hydrophobic cluster analysis (HCA) of the hormone-binding domain of receptor proteinsJournal of Steroid Biochemistry, 1989
- Organometallic derivatives of estradiol as bioligands: Targetted binding of the estradiol receptorJournal of Steroid Biochemistry, 1989
- Application of Organotransition Metal Carbonyl Complexes as Infrared Markers for Hormonal Steroids in Biological ProcessesComments on Inorganic Chemistry, 1989
- The use of high affinity binding bioligands modified by transition metal carbonyl moietiesPublished by Walter de Gruyter GmbH ,1989
- Hydrophobic cluster analysis: An efficient new way to compare and analyse amino acid sequencesFEBS Letters, 1987
- Organometallic derivatives of hormonal steroids: 500-MHz one- and two-dimensional NMR spectra of 17.alpha.-propynylestra-1,3,5(10)-triene-3,17.beta.-diol and its Co2(CO)6 and (C5H5)2Mo2(CO)4 complexesThe Journal of Organic Chemistry, 1986
- Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-ANature, 1986
- Steroid Receptors in Breast CancerNew England Journal of Medicine, 1979
- Reactions of ferrocenyl-stabilised carbocations with water: substituent, medium, salt, and solvent isotope effects on rates and equilibriaJournal of the Chemical Society, Perkin Transactions 2, 1979
- Östradiol- und Östron-Ester der [103Ru]Ruthenocencarbonsäure Synthese, Exkretion und OrganverteilungHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1977