Percolation and Release of Cisplatin Loaded in Poly(lactide-co-glycolide) Microspheres for Chemoembolization
- 1 April 1992
- journal article
- Published by SAGE Publications in Journal of Bioactive and Compatible Polymers
- Vol. 7 (2), 149-160
- https://doi.org/10.1177/088391159200700203
Abstract
The dissolution kinetics, in an aqueous medium, of a water solu ble drug dispersed in an insoluble polymeric matrix, depends highly on the drug loading. A computer model of cisplatin loaded poly(lactide-co-glycolide) microspheres dissolution confirms the hypothesis that only the drug crystals connected to the surface of the microspheres are capable of dissolving through a site percolation mechanism. This behavior may also be possible with other drug release systems, limiting their use for controlled release.Keywords
This publication has 9 references indexed in Scilit:
- In vitro and In vivo degradation of poly(D,L lactide/glycolide) type microspheres made by solvent evaporation methodBiomaterials, 1989
- Biodegradable cisplatiim microspheres prepared by the solvent evaporation method: Morphology and release characteristicsJournal of Controlled Release, 1988
- Formation and Characterization of Cisplatin Loaded Poly(d,l-Lactide) Microspheres for ChemoembolizationJournal of Pharmaceutical Sciences, 1986
- Arterial chemoembolization with cisplatin microcapsulesBritish Journal of Cancer, 1986
- Charles F. Kettring prize. Fundamental studies with cisplatinCancer, 1985
- Percolation in hard-core lattice gases and a model ferrofluidJournal of Statistical Physics, 1985
- Arterial Chemoembolization With Microencapsulated Anticancer DrugPublished by American Medical Association (AMA) ,1981
- Site percolation in randomly packed spheresPhysical Review B, 1979
- Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matricesJournal of Pharmaceutical Sciences, 1963