The integrin α10 subunit: expression pattern, partial gene structure, and chromosomal localization
- 1 July 1999
- journal article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 87 (3-4), 238-244
- https://doi.org/10.1159/000015434
Abstract
Herein we report the cloning of cDNAs and incompletely processed hnRNAs from endothelia and heart that encode the α10 subunit forming part of the novel collagen type II-binding integrin α10β1 of chondrocytes. Analysis of hnRNA clones and reported expressed sequence tags revealed the positions of 17 putative intron-exon splice junctions shared with those of the p150,95 (ITGAX) gene. Human α10 transcripts of 5.4 and 1.8 kb were not restricted to chondrocytes but, instead, were widely expressed in a panel of 24 tissue types, where the highest expression was found in muscle and heart. The human α10 subunit gene (ITGA10) was localized to band q21 of chromosome 1.Keywords
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