Synthesis of polyamide containing optically active thymine derivative as a grafted pendant
- 1 February 1986
- journal article
- research article
- Published by Wiley in Journal of Polymer Science Part A: Polymer Chemistry
- Vol. 24 (2), 269-278
- https://doi.org/10.1002/pola.1986.080240206
Abstract
A new route to polyamides containing optically active thymine groups as pendants has been established. The method is based on the grafting of (–) and (±)‐2‐(thymin‐1‐yl)propionic acid [(–) and (±) TPA] onto a polyamide containing hydroxyl groups. The hydroxy polyamide was prepared by selective N‐acylation of an active diester of N‐hydroxy‐5‐norborene‐2,3‐dicarboxamide (HONB), N,N'‐(isophthaloyl‐dioxy)‐bis(5‐norbornene‐2,3‐dicarboximide) (IPBONB), with 1,3‐diamino‐2‐hydroxypropane (AHP). Model compounds (−) and (±)‐(1,3‐dibenzoylamino‐2‐propyl)2‐(thymin‐1‐yl)propionate[(−) and (±) (BAPTP)] were prepared by direct, low‐temperature esterification before synthesizing the polymer.This publication has 4 references indexed in Scilit:
- Direct, low‐temperature esterification: Synthesis of optically active esters of thymine derivativesJournal of Polymer Science Part C: Polymer Letters, 1984
- Synthesis of polyamides from active O,O′‐diacyl derivatives of N‐hydroxy compounds and diamines under mild conditionsJournal of Polymer Science: Polymer Chemistry Edition, 1981
- Syntheses of polyethylenimine containing asymmetric nucleic acid base derivatives as grafted pendantsJournal of Polymer Science: Polymer Chemistry Edition, 1980
- Synthesis of Polyamides from N-Malonic Diesters of Uracil and TheophyllinePolymer Journal, 1977