Cure of Hematologic Neoplasia with Transplantation of Marrow from Identical Twins

Abstract

IN 1974, we reported¹ on 16 patients with refractory hematologic neoplasia who were treated with high-dose cyclophosphamide, supralethal total-body irradiation, bone-marrow transplantation from a normal genetically identical twin and, most often, "immunotherapy" in the form of their own killed tumor cells in addition to normal twin lymphocytes. Six patients then experienced complete remissions of 11 months or longer. This report updates the status of the same six patients, who continue to be free of neoplasia four to 6 1/2 years after transplantation without any post-transplant chemotherapy.ResultsThe critical data are presented in the case histories and in Table 1. Descriptions . . .