Carotid Intima-Media Thickening Indicates a Higher Vascular Risk Across a Wide Age Range
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- 1 January 2006
- journal article
- research article
- Published by Wolters Kluwer Health in Stroke
- Vol. 37 (1), 87-92
- https://doi.org/10.1161/01.str.0000196964.24024.ea
Abstract
Background and Purpose— Carotid intima-media thickness (IMT) is an independent predictor of vascular events in age groups >45 years. However, there is little information about the predictive value of IMT in younger individuals. Methods— In the Carotid Atherosclerosis Progression Study (CAPS; n=5056; age range 19 to 90 years; mean age 50.1 years), common carotid artery (CCA) IMT, bifurcation IMT, internal carotid artery IMT and vascular risk factors were evaluated at baseline. The incidence of stroke, myocardial infarction (MI), and death was determined prospectively. Data for younger (<50 years; n=2436) and older subjects (≥50 years; n=2620) were analyzed separately using Cox proportional hazard regression models. Results— During a mean follow-up period of 4.2 years, there were 228 cases of MI, 107 strokes, and 50 deaths. IMT at all carotid segments was highly predictive of all end points (eg, hazard rate ratios [HRRs] per 1 SD CCA-IMT increase were 1.43 [95% CI: 1.35 to 1.51] for MI, 1.47 [1.35 to 1.60] ...Keywords
This publication has 14 references indexed in Scilit:
- Effects of statin therapy on the progression of carotid atherosclerosis: a systematic review and meta-analysisAtherosclerosis, 2004
- Carotid Intima-Media Thickness and Plaque Characteristics as a Risk Factor for Stroke in Japanese Elderly MenStroke, 2004
- Rates and Determinants of Site-Specific Progression of Carotid Artery Intima-Media ThicknessStroke, 2004
- Atherosclerosis measured by B-Mode ultrasonography: effect of statin therapy on disease progressionAmerican Journal Of Medicine, 2004
- Comparison Between Measures of Atherosclerosis and Risk of StrokeStroke, 2003
- Interleukin-6 Promoter Polymorphism Modulates the Effects of Heavy Alcohol Consumption on Early Carotid Artery AtherosclerosisStroke, 2003
- Early Carotid Atherosclerosis and Family History of Vascular DiseaseArteriosclerosis, Thrombosis, and Vascular Biology, 2003
- Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studiesThe Lancet, 2002
- Carotid intima-media thickness at different sites: relation to incident myocardial infarction. The Rotterdam StudyEuropean Heart Journal, 2002
- Carotid-Artery Intima and Media Thickness as a Risk Factor for Myocardial Infarction and Stroke in Older AdultsNew England Journal of Medicine, 1999