Spheciosterol Sulfates, PKCζ Inhibitors from a Philippine Sponge Spheciospongia sp.
Open Access
- 18 June 2008
- journal article
- review article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 71 (7), 1213-1217
- https://doi.org/10.1021/np8001628
Abstract
Three new sterol sulfates, spheciosterol sulfates A−C (1−3), and the known sterol sulfate topsentiasterol sulfate E (4) have been isolated from the sponge Spheciospongia sp., collected in the Philippines. Structures were assigned on the basis of extensive 1D and 2D NMR studies as well as analysis by HRESIMS. Compounds 1−4 inhibited PKCζ with IC50 values of 1.59, 0.53, 0.11, and 1.21 μM, respectively. In a cell-based assay, 1−4 also inhibited NF-κB activation with EC50 values of 12−64 μM.Keywords
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