Controlled Trial of 3-Day Quinine-Clindamycin Treatment versus 7-Day Quinine Treatment for Adult Travelers with Uncomplicated Falciparum Malaria Imported from the Tropics
Open Access
- 1 March 2001
- journal article
- clinical trial
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 45 (3), 932-935
- https://doi.org/10.1128/aac.45.3.932-935.2001
Abstract
We conducted a randomized, double-blind, placebo-controlled trial to compare a 3-day quinine-clindamycin regimen (group QC) with a 7-day quinine regimen (group Q) for the treatment of uncomplicatedPlasmodium falciparum malaria in travelers returning from the tropics. A total of 55 and 53 patients in groups Q and QC were analyzed, respectively. Adverse effects were similar in both groups, although two patients in group Q had severe adverse reactions, leading to the cessation of treatment. The 28-day cure rate for the evaluated patients (per-protocol analysis) was 100% for group QC, whereas it was 96.3% for group Q (P = 0.5). The 28-day cure rate in the intention-to-treat analysis was 96.2% for group QC, whereas it was 94.6% for group Q (P = 1). There were no significant differences between the two regimens with regard to parasite and fever clearance times. Our study shows that the 3-day quinine-clindamycin regimen is well tolerated and compares favorably with a 7-day quinine treatment. This short-term regimen had previously been evaluated only in areas of endemicity. According to our results, the 3-day quinine-clindamycin regimen may be an alternative for the treatment of imported uncomplicated P. falciparum malaria in travelers returning from the tropics.Keywords
This publication has 9 references indexed in Scilit:
- Dealing with and preventing imported malaria due to Plasmodium falciparumMedecine Et Maladies Infectieuses, 1999
- Therapeutic efficacy of clindamycin in combination with quinine for treating uncomplicated malaria in a village dispensary in Gabon.Tropical Medicine & International Health, 1997
- The Treatment of MalariaNew England Journal of Medicine, 1996
- Quinine plus clindamycin improves chemotherapy of severe malaria in childrenAntimicrobial Agents and Chemotherapy, 1995
- High efficacy of short-term quinine-antibiotic combinations for treating adult malaria patients in an area in which malaria is hyperendemicAntimicrobial Agents and Chemotherapy, 1995
- Clindamycin in Combination with Chloroquine or Quinine Is an Effective Therapy for Uncomplicated Plasmodium falciparum Malaria in Children from GabonThe Journal of Infectious Diseases, 1994
- QT prolongation and sudden cardiac death in patients with alcoholic liver diseaseThe Lancet, 1993
- Cardiac effects of antimalarial treatment with halofantrineThe Lancet, 1993
- A Comparative Trial of Three Regimens for Treating Uncomplicated Falciparum Malaria in Acre, BrazilThe Journal of Infectious Diseases, 1988