Neuroleptic-induced supersensitivity psychosis: clinical and pharmacologic characteristics
- 1 January 1980
- journal article
- research article
- Published by American Psychiatric Association Publishing in American Journal of Psychiatry
- Vol. 137 (1), 16-21
- https://doi.org/10.1176/ajp.137.1.16
Abstract
Tardive dyskinesia is thought to result from neostriatal dopaminergic receptor supersensitivity induced by chronic treatment with neuroleptics. Dopaminergic supersensitivity may also occur in the mesolimbic region after chronic neuroleptic exposure, resulting in the development of a supersensitivity psychosis. Neuroleptic-induced supersensitivity psychosis is illustrated by data from 10 patients that demonstrate the syndrome''s clinical and pharmacologic characteristics. An implication of neuroleptic-induced mesolimbic supersensitivity is that the tendency toward psychotic relapse in such patients is determined by more than just the normal course of the illness.This publication has 11 references indexed in Scilit:
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