The dnaA gene product is not required during stable chromosome replication in Escherichia coli
- 1 December 1980
- journal article
- research article
- Published by Springer Nature in Molecular Genetics and Genomics
- Vol. 180 (3), 617-620
- https://doi.org/10.1007/bf00268069
Abstract
Exposure of Escherichia coli dnaA strains to UV light results in a transient resumption of chromosome replication at 42° C, the temperature restrictive to these mutants, Capability of dnaA mutants to replicate DNA at 42° C can be stabilized, however, when either protein or RNA synthesis is inhibited 60 min after UV irradiation. DNA synthesis proceeds for several hours under these conditions. These results indicate that dnaA dependent transcription is not involved in initiation of chromosome cycles during stable DNA synthesis.This publication has 13 references indexed in Scilit:
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