The synthesis of nephrotoxic conjugates of glutathione and cysteine
- 1 April 1988
- journal article
- research article
- Published by Taylor & Francis in Toxicological & Environmental Chemistry
- Vol. 17 (2), 153-162
- https://doi.org/10.1080/02772248809357287
Abstract
New methods for the preparation and purification of nephrotoxic cysteine conjugates of chloro‐ and fluoro‐alkenes are described. The methods are applicable to a wide range of cysteine, N‐acetyl cysteine and glutathione conjugates and examples have been given of the synthesis and characterisation of two novel glutathione conjugates.Keywords
This publication has 9 references indexed in Scilit:
- Structure/activity studies of the nephrotoxic and mutagenic action of cysteine conjugates of chlgro and fluoroalkenesChemico-Biological Interactions, 1985
- The metabolism and nephrotoxicity of tetrafluoroethylene in the ratToxicology and Applied Pharmacology, 1984
- The metabolism and disposition of hexachloro-1:3-butadiene in the rat and its relevance to nephrotoxicityToxicology and Applied Pharmacology, 1984
- Effect of halogenated vinyl cysteine conjugates on renal tubular active transportToxicology, 1983
- Stereoselective activation of vicinal dihalogen compounds to mutagens by glutathione conjugationBiochemical Pharmacology, 1979
- Rapid chromatographic technique for preparative separations with moderate resolutionThe Journal of Organic Chemistry, 1978
- The mutagenic effect of 1,2-dichloroethane on Salmonella typhimurium I. Activation through conjugation with glutathion in vitroChemico-Biological Interactions, 1977
- Chronic Toxicity and Reproduction Studies of Hexachlorobutadiene in RatsEnvironmental Health Perspectives, 1977
- Possible Toxic Factor of Trichloroethylene-extracted Soybean Oil Meal3Journal of the American Chemical Society, 1959