The Golden Hamster (Cricetus auratus) as an Experimental Animal for Poliomyelitis Research.

Abstract

Golden hamsters from 2 sources presented marked differences in susceptibility to the Lansing strain of poliomyelitis virus. Both strains were markedly inferior to the white mouse and the cotton rat as exptl. animals for poliomyelitis research. The use of the autolyzed normal mouse brain technique did not increase the infectivity of the virus for the hamster, while the adjustment of the inoculum at a low pH gave inconsistent results. Intraperit. inoculations of mouse-passage and cotton-rat-pas-sage virus resulted in higher titers of neutralizing antibody than when hamster-passage virus was used.