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Abstract
Pancreatic adenocarcinoma is the fourth leading cause of cancer death in the United States1 and is responsible for about 227 000 deaths per year worldwide.2 Because of the lack of effective screening tests for pancreatic cancer, it is often diagnosed at an advanced stage, contributing to a 5-year survival rate that is less than 5%.3 The incidence of pancreatic cancer is higher in men than in women, and in the United States, it is higher in blacks than in whites.3 Smoking, diabetes mellitus, and a family history of pancreatic cancer are known risk factors,4,5 but these factors do not account for all the cases of pancreatic cancer.