INDUCIBLE NITRIC OXIDE SYNTHASE IN THE BLADDER OF SPINAL CORD INJURED PATIENTS WITH A CHRONIC INDWELLING URINARY CATHETER
- 1 May 2001
- journal article
- Published by Wolters Kluwer Health in Journal of Urology
- Vol. 165 (5), 1457-1461
- https://doi.org/10.1016/s0022-5347(05)66327-6
Abstract
Conclusions Inducible nitric oxide synthase is expressed in inflammatory macrophages in areas of chronic inflammation in the bladder mucosa of spinal cord injured patients with a chronic indwelling bladder catheter. The expression of inducible nitric oxide synthase may potentially lead to the sustained production of nitric oxide and its oxidative products, the nitrosation of urinary amines and the formation of potentially carcinogenic nitrosamines in the bladder.Keywords
This publication has 17 references indexed in Scilit:
- BLADDER HISTOLOGICAL CHANGES ASSOCIATED WITH CHRONIC INDWELLING URINARY CATHETERJournal of Urology, 1999
- Bacterial infection induces nitric oxide synthase in human neutrophils.Journal of Clinical Investigation, 1997
- Risk Factors for Bladder Tumors in Spinal Cord Injury PatientsJournal of Urology, 1996
- [16] Nitrotyrosine as biomarker for reactive nitrogen speciesMethods in Enzymology, 1996
- Potential genotoxicity of chronically elevated nitric oxide: A reviewMutation Research/Reviews in Genetic Toxicology, 1995
- Role of N-nitroso compounds (NOC) and N-nitrosation in etiology of gastric, esophageal, nasopharyngeal and bladder cancer and contribution to cancer of known exposures to NOCCancer Letters, 1995
- Nitrate, nitrite and volatile N-nitroso compounds in the urine of Schistosoma haematobium and Schistosoma mansoni infected patientsCarcinogenesis: Integrative Cancer Research, 1994
- Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesisMutation Research, 1994
- N-nitrosamine generation by urinary tract infections in spine injured patientsSpinal Cord, 1992
- The incidence of bladder cancer in paraplegiaSpinal Cord, 1966