High Activity of Potent Analgesics on Conditioned Rat Tranquilizer Test
- 1 August 1959
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 101 (4), 594-596
- https://doi.org/10.3181/00379727-101-25029
Abstract
The analgesics codeine, morphine, and 1-14-hydroxydihydromorphinone (Numorphan) produced inhibition of the conditioned avoidance-escape response in rats, a widely used tranquilizer test. The potencies in blocking the conditioned response correlated roughly with the analgesic potencies determined in mice by thehot-plate method, and with figures reported in the literature for analgesia in man. The very potent analgesic, l-14-hydroxydihydro-morphinone, exhibited by subcutaneous injection slightly more conditioned response blocking activity than perphenazine, one of the most active tranquilizers now in clinical use, and much more activity than morphine.Keywords
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- THE INHIBITION OF THE CONDITIONED RESPONSE AND THE COUNTERACTION OF SCHIZOPHRENIA BY MUSCARINIC STIMULATION OF THE BRAINAnnals of the New York Academy of Sciences, 1957
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