Serum alpha‐fetoprotein as a marker for the effect of post‐operative radiation therapy and/or chemotherapy in eight cases of ovarian endodermal sinus tumour
- 15 November 1976
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 18 (5), 574-580
- https://doi.org/10.1002/ijc.2910180505
Abstract
The clinical pathological findings of eight cases of ovarian endodermal sinus tumour (yolk sac tumour) are presented. Histological examination in all eight cases showed a typical endodermal sinus tumour pattern, and in six of the patients other tumour elements such as dysgerminoma, choriocarcinoma, malignant teratoma, endometriosis, and a dermoid cyst were also found. Six patients had increased serum alpha-fetoprotein concentration in the postoperative period, and two patients had a normal concentration 27 and 35 days after operation, respectively. In all cases except one, a close correlation between serum alpha-fetoprotein and progression or regression of tumour was found. Serum alpha-fetoprotein was thus found to be a reliable parameter in post-operative radiation and/or chemotherapy (VAMBLE). In one patient who died 10 months after operation with widespread endodermal sinus tumour growth, only a small terminal increase in serum alpha-fetoprotein concentration was found. Four of the eight women are still alive with normal alpha-fetoprotein concentration, and without clinical evidence of tumour disease.This publication has 13 references indexed in Scilit:
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